题目：

Dual-Targeted Multifunctional Nanoparticles for Magnetic Resonance Imaging Guided Cancer Diagnosis and Therapy

作者：

Xueyan Nan,^† Xiujuan Zhang,^*,† Yanqiu Liu,^† Mengjiao Zhou,^† Xianfeng Chen,^*,‡ and Xiaohong Zhang^*,†

单位：

^†Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials &

Devices, Soochow University, Suzhou Jiangsu 215123, P. R. China

^‡Institute for Bioengineering, School of Engineering, University of Edinburgh, Edinburgh EH9 3JL, United Kingdom

摘要：

Hybrid nanostructures with combined functionalitiescan be rationally designed to achieve synergistic effects for efficientcancer treatment. Herein, a multifunctional nanoplatform isconstructed, containing an inner core of an anticancer drug MTXsurrounding by a nanometer-thin layer of gold as the shell with Fe₃O₄magnetic nanoparticles (NPs) evenly distributed in the gold layer,and the outermost hybrid LA-PEG-MTX molecules as surface coatingagent (denoted as MFG-LPM NPs). This nanocomposite possessesvery high drug loading capacity as the entire core is MTX andintegrates magnetic- and active- targeting drug delivery, lightcontrolled drug release, magnetic resonance imaging (MRI), as wellas photothermal and chemotherapy. With a strong near-infrared(NIR) absorbance at 808 nm, the nanocomposite enables temperature elevation and light-triggered MTX release. In vitro cytotoxicity studies indicate that the strategy of combining therapy leadsto a synergistic effect with high cancer cell killing efficacy. In consistency with this, due to the high accumulation of MFG-LPMNPs at tumor site and their combinatorial chemo-photothermal effects, 100% in vivo tumor elimination can be achieved.Additionally, in vivo MRI of tumor-bearing mice demonstrates an impressive performance of MFG-LPM NPs as a T₂ contrastagent. Therefore, such multifunctional nanocomposite has the potential to serve as an excellent theranostic agent that collectively integrates multiple functions for efficient MRI guided cancer diagnosis and treatment.

影响因子：

7.145

分区情况：

一区

链接：

http://pubs.acs.org/doi/abs/10.1021/acsami.6b16486