题目：

Bottom-Up Preparation of Uniform Ultrathin Rhenium Disulfide Nanosheets for Image-Guided Photothermal Radiotherapy

作者：

Sida Shen¹, Yu Chao¹, Ziliang Dong¹, Guanglin Wang², Xuan Yi², Guosheng Song¹, Kai Yang²,Zhuang Liu¹, and Liang Cheng*¹

单位：

¹Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Collaborative Innovation Center of Suzhou, Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China

²School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection,  Soochow University, Suzhou, Jiangsu 215123, China

摘要：      

Facile preparation of multifunctional theranostic nanoplatforms with well-controlled morphology and sizes remains an attractive in the area of nanomedicine. Here, a new kind of 2D transition metal dichalcogenide, rhenium disulfide (ReS₂) nanosheets, with uniform sizes, strong near-infrared (NIR) light, and strong X-ray attenuation, is successfully synthesized. After surface modification with poly (ethylene glycol) (PEG), the synthesizedReS₂-PEG nanosheets are stable in various physiological solutions. In addition to their contrasts in photoacoustic imaging and X-ray computed tomography imaging because of their strong NIR light and X-ray absorptions, respectively, such ReS₂-PEG nanosheets can also be tracked under nuclear imaging after chelator-free labeling with radioisotope ions, ^99mTc⁴⁺. Efficient tumor accumulation of ReS₂-PEG nanosheets is then observed after intravenous injection into tumor-bearing mice under triple-modal imaging. The combined in vivo photothermal radiotherapy is further conducted, achieving a remarkable synergistic tumor destruction effect. Finally, no obvious toxicity of ReS₂-PEG nanosheets is observed from the treated mice within 30 d. This work suggests that such ultrathin ReS₂ nanosheets with well-controlled morphology and uniform sizes may be a promising type of multifunctional theranostic agent for remotely triggered cancer combination therapy.

影响因子：

12.124

分区情况：

1区

链接：

http://onlinelibrary.wiley.com/doi/10.1002/adfm.201700250/full

 责任编辑：向丹婷 联系方式：dtxiang@suda.edu.cn