题目：

Iodine-131-Labeled, Transferrin-Capped Polypyrrole Nanoparticles for Tumor-Targeted Synergistic Photothermal-Radioisotope Therapy

作者：

Xuejiao Song,^‡a Chao Liang,^‡a Liangzhu Feng,^a Kai Yang,*^b and Zhuang Liu*^a

单位：

^a Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Jiangsu 215123, China

^b School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X) Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection Soochow University Suzhou, Jiangsu 215123, China

摘要：

Combining different therapeutic functions within single tumor-targeted nanoscale delivery systems is promising to overcome the limitations of conventional cancer therapies. Herein, transferrin that recognizes transferrin receptors up-regulated on tumor cells is pre-labeled with iodine-131 (¹³¹I) and then utilized as the stabilizer in the fabrication of polypyrrole (PPy) nanoparticles. The obtained transferrincapped PPy@Tf-¹³¹I nanoparticles could be used for tumor-targeted radioisotope therapy (RIT) and photothermal therapy (PTT), by employing beta-emission from ¹³¹I and the intrinsic high near-infrared (NIR) absorbance of PPy, respectively. Owing to the transferrin-mediated tumor targeting, PPy@Tf-¹³¹I nanoparticles exhibit obviously enhanced in vitro cancer cell binding and in vivo tumor uptake compared to its non-targeting counterpart. The combined RIT and PTT based on PPy@Tf-¹³¹I nanoparticles is then conducted, achieving a remarkable synergistic therapeutic effect. This work thus demonstrates a rather simple one-step approach to fabricate tumor-targeting nanoparticles based on proteincapped conjugated polymers, promising for combination cancer therapy with great efficacy and high safety.

影响因子：

4.21

分区情况：

二区

链接：

http://pubs.rsc.org/en/content/articlehtml/2017/bm/c7bm00409e