题目：

Hollow MnO₂ as a Tumor-Microenvironment-ResponsiveBiodegradable Nano-Platform for Combination Therapy Favoring Antitumor Immune Responses

作者：

Guangbao Yang, Ligeng Xu, Yu Chao, Jun Xu, Xiaoqi Sun, Yifan Wu, RuiPeng & Zhuang Liu^*

单位：

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu 215123, China

摘要：

Herein,an intelligent biodegradable hollow manganese dioxide (H-MnO₂)nano-platform is developed for not only tumor microenvironment (TME)-specificimaging and on-demand drug release, but also modulation of hypoxic TME to enhancecancer therapy, resulting in comprehensive effects favoring anti-tumor immuneresponses. With hollow structures, H-MnO₂ nanoshells postmodification with polyethylene glycol (PEG) could be co-loaded with aphotodynamic agent chlorine e6 (Ce6), and a chemotherapy drug doxorubicin(DOX). The obtained H-MnO₂-PEG/C&D would be dissociated underreduced pH within TME to release loaded therapeutic molecules, and in the meantime induce decomposition of tumor endogenous H₂O₂ to relievetumor hypoxia. As a result, a remarkable in vivo synergistic therapeuticeffect is achieved through the combined chemo-photodynamic therapy, which simultaneouslytriggers a series of anti-tumor immune responses. Its further combination withcheckpoint-blockade therapy would lead to inhibition of tumors at distant sites,promising for tumor metastasis treatment.

影响因子：

12.124

分区情况：

一区

链接：

https://www.nature.com/articles/s41467-017-01050-0