作者：

Shunhu Zhang^1#, Nailin Yang^2#, Haitao Zhao¹, Shumin Sun², Peidong Chen¹, Chaowei Cheng¹, Chunjie Wang², Weiwei He³*, Lifen Zhang¹*, Liang Cheng²*, Zhenping Cheng¹*

单位：

¹State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Suzhou key Laboratory of Macromolecular Design and Precision Synthesis College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 China

²Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, China

³State Key Laboratory of Radiation Medicine and Protection School of Radiological and Interdisciplinary Sciences (RADX) Soochow University Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Suzhou 215123 China

摘要：

Chemical structure plays a critical role in determining the properties and aggregation behavior of materials. In this study, controlled axial modification of one or two PEG₅₀₀₀ molecules is performed on the central metal (Sn) of the fluorinated phthalocyanine to obtain asymmetric and symmetric amphiphilic polymers, denoted as SnPcP and SnPc2P, respectively. The anisotropic aggregation of fluorinated phthalocyanine guides the construction of dynamic aggregates with diverse architectures. Dynamic aggregates can be formed by seed-growth at high concentrations in selective solvents, detaching into pseudo-axisymmetric J-aggregated oligomers (seeds, <20 nm) at low concentrations for the asymmetric SnPcP. For SnPc2P, the symmetrically entangled PEG prevents the orderly arrangement of fluorinated phthalocyanine and forms seeds independently; aggregates are preferred at high concentrations, and unimers (seeds, ca. 10 nm) can be obtained when diluted. Both photosensitizers (PSs) exhibit outstanding photostability and oxygen-carrying capacity, and additionally, SnPcP displays higher photodynamic efficiency at low concentrations, probably due to that J-aggregation elevates the intersystem crossing efficiency. In vitro and in vivo experiments demonstrate the extraordinary photodynamic therapy capacity of SnPcP. This study provides a universal strategy for the modular design of dynamic aggregates by constructing detachable PS primitives with pseudo/axisymmetric structures.

影响因子：

19.0

分区情况：

一区

链接：

https://doi.org/10.1002/adfm.202513920