Nanoscale CaH₂ materials for synergistic hydrogen-immune cancer therapy

作者：

Fei Gong^1,# , Jiachen Xu^2,# , Bo Liu^1,# , Nailin Yang^1,# , Liang Cheng^1,* , Peng Huang², Chunjie Wang¹, Qian Chen¹, Caifang Ni^2,* , and Zhuang Liu^1,*

单位：

¹Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, China

²Department of Interventional Radiology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China

摘要：

Herein, we prepared CaH₂ nanoparticles through liquid-phase exfoliation and first applied them as an antitumor therapeutic agent. Being dispersed in low-molecular-weight polyethylene glycol (PEG) and injected into the tumor, nano-CaH₂ would react with water to generate abundant hydrogen gas (H₂), calcium ions (Ca²⁺), and hydroxyl ions (OH-), enabling hydrogen therapy, tumor calcification, and neutralization of acidic tumor microenvironment (TME), respectively. The injectable nano-CaH₂ dispersion could lead to significant tumor growth inhibition. In addition, the local nano-CaH₂-induced tumor cell apoptosis and TME modulation would activate the immune system and promote tumor infiltration of immune cells, which, working together with immune checkpoint blockade, could elicit robust immune responses to inhibit abscopal distant tumors without direct nano-CaH₂ injection. Furthermore, nano-CaH₂ could be dispersed in lipiodol to obtain CaH₂-lipiodol dispersion for interventional transarterial embolization (TAE) therapy, and they showed obviously improved TAE therapeutic outcome on orthotopic rabbit liver cancer model compared with ipiodol alone.

影响因子：

22.804

分区情况：

一区

链接：

https://www.sciencedirect.com/science/article/pii/S245192942100591X