题目：

Bimetallic Oxide MnMoO_X Nanorods for in Vivo PhotoacousticImaging of GSH and Tumor-Specific Photothermal Therapy

作者：

Fei Gong,^† Liang Cheng,*,^† Nailin Yang,^† Qiutong Jin,^† Longlong Tian,^† Mengyun Wang,^‡Yonggang Li,^‡ and Zhuang Liu*,^†

单位：

^†Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials andDevices, Soochow University, Suzhou 215123, China

^‡Department of Radiology, The First Affiliated Hospital of Soochow University Suzhou, Jiangsu 215006, China

摘要：

Accurate imaging of glutathione (GSH) in vivois able to provide real-time visualization of physiological andpathological conditions. Herein, we successfully synthesizebimetallic oxide MnMoO_X nanorods as an intelligent nanoprobefor in vivo GSH detection via photoacoustic (PA) imaging.The obtained MnMoO_X nanoprobe with no near-infrared(NIR) absorption in the absence of GSH would exhibit strongGSH-responsive NIR absorbance, endowing PA imagingdetection of GSH. Due to the up-regulated GSH concentrationin the tumor microenvironment, our MnMoO_X nanoprobecould be utilized for in vivo tumor-specific PA imaging.Moreover, MnMoO_X nanorods with GSH-responsive NIRabsorbance could also be employed to achieve tumor-specificphotothermal therapy (PTT). Importantly, such MnMoO_X nanorods show inherent biodegradability and could be rapidlycleared out from the body, minimizing their long-term body retention and potential toxicity. Our work presents a new type of GSH-responsive nanoprobe based on bimetallic oxide nanostructures, promising for tumor-specific imaging and therapy

影响因子：

12.080

分区情况：

一区

链接：

https://pubs.acs.org/doi/abs/10.1021/acs.nanolett.8b02933