单位： | Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University,Suzhou, Jiangsu 215123, China
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摘要： | Cancer, one of major threats to the human health, possesses intricate structure and constituents distinctivefrom normal organs and tissues. It has been well recognized that the unique tumor microenvironment(TME) would promote tumor progression and metastases, and in the meanwhile result in resistance oftumors to different types of therapies. Therefore, modulation of TME, instead of directly killing tumorcells, has been proposed as an alternative approach to improve the therapeutic outcomes of current cancertherapies. In this regard, nanomedicine strategies have shown significant potential as intensively reportedin recent years. In this review, we would like to summarize the latest efforts utilizing nanomedicine tomodulate various features within the microenvironment of solid tumors, including tumor hypoxia, tumor pH, the extracellular matrix, as well as the immune microenvironment within the tumor. The therapeuticbenefits after such treatments, especially in combination with many existing cancer therapies, will beintroduced. On the other hand, how the modulation of TME would in turn favor the therapeutic efficacyof nanomedicine, will also be discussed. The future perspectives of those strategies, especially towardsclinical translation, will be addressed in the end.
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