题目：

Nanoscale Metal−Organic Particles with Rapid Clearance for Magnetic Resonance Imaging-Guided Photothermal Therapy

作者：

Yu Yang,^† Jingjing Liu,^‡ Chao Liang,^‡ Liangzhu Feng,^‡ Tingting Fu,^§ Ziliang Dong,^‡ Yu Chao,^‡ Yonggang Li,^§ Guang Lu,*^,‡ Meiwan Chen,*^,† and Zhuang Liu*^,‡

单位：

^†State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidad, Taipa, Macau, China

^‡Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu 215123, China

^§Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China

摘要：

Nanoscale metal−organic particles (NMOPs) are constructed from metal ions and organic bridging ligands via the self-assembly process. Herein, we fabricate NMOPs composed of Mn²⁺ and a near-infrared (NIR) dye, IR825, obtaining Mn-IR825 NMOPs, which are then coated with a shell of polydopamine (PDA) and further functionalized with polyethylene glycol (PEG). While Mn²⁺ in such Mn-IR825@PDA−PEG NMOPs offers strong contrast in T1-weighted magnetic resonance (MR) imaging, IR825 with strong NIR optical absorbance shows efficient photothermal conversion with great photostability in the NMOP structure. Upon intravenous injection, Mn-IR825@PDA−PEG shows efficient tumor homing together with rapid renal excretion behaviors, as revealed by MR imaging and confirmed by biodistribution measurement. Notably, when irradiated with an 808 nm laser, tumors on mice with Mn-IR825@PDA−PEG injection are completely eliminated without recurrence within 60 days, demonstrating the high efficacy of photothermal therapy with this agent. This study demonstrates the use of NMOPs as a potential photothermal agent, which features excellent tumortargeted imaging and therapeutic functions, together with rapid renal excretion behavior, the latter of which would be particularly important for future clinical translation of nanomedicine.

影响因子：

12.881

分区情况：

1区

链接：

http://pubs.acs.org/doi/abs/10.1021/acsnano.5b07882

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