题目：

Intelligent Albumin-MnO₂ Nanoparticles as pH-/H₂O₂-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy

作者：

Qian Chen, Liangzhu Feng, Jingjing Liu, Wenwen Zhu, Ziliang Dong, Yifan Wu, Zhuang Liu*

单位：

Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, 199 Ren’ai Road, Suzhou 215123, Jiangsu, P. R. China

摘要：

A unique type of pH/H₂O₂ dual-responsive intelligent nanoscale delivery system based on albumin-coated MnO₂ is presented, which is capable of modulating the tumor microenvironment (TME) by relieving hypoxia. Additionally, TME-responsive size changes enable effective intratumor diffusion. A highly effective combined photodynamic and chemotherapy is realized with these nanoparticles in a mouse tumor model.

影响因子：

18.960

分区情况：

1区

链接：

http://onlinelibrary.wiley.com/doi/10.1002/adma.201601902/full