题目：

Degradable Vanadium Disulfide Nanostructures with Unique Optical and Magnetic Functions for Cancer Theranostics

作者：

Yuyan Chen, Liang Cheng,^* Ziliang Dong, Yu Chao, Huali Lei,   He Zhao, Jian Wang, and Zhuang Liu^*

单位：

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Jiangsu 215123, China

摘要：

Multifunctional biodegradable inorganic theranostic nano-agents are of great interest to the field of nanomedicine. Upon lipid modification, VS₂ nanosheets could be converted into ultra-small VS₂ nanodots encapsulated inside polyethylene glycol (PEG) modified lipid micelles. Owing to paramagnetism, high near-infrared (NIR) absorbance, and chelator-free99mTc⁴⁺ labeling of VS₂, such VS₂@lipid-PEG nanoparticlescould be used for T1-weighted magnetic resonance (MR),photoacoustic (PA),and single photon emission computedtomography (SPECT) tri-modal imaging guided photothermalablation of tumors. Importantly, along with the gradualdegradation of VS₂, our VS2@lipid-PEG nanoparticles exhibiteffective body excretion without appreciable toxicity. Theunique advantages of VS₂ nanostructures with highly integrated functionalities and biodegradable behaviors mean they are promising for applications in cancer theranostics.

影响因子：

11.994

分区情况：

一区

链接：

http://onlinelibrary.wiley.com/doi/10.1002/anie.201707128/full