作者： | Muchao Chen1#, Jiaying Hu1#, Huiqin Gao2,3, Jingjing Shen1, Ting Wei1, Jing Yao4, Yan Zhang5, Ping Gu2,3, Zhuang Liu1, Qian Chen1* |
单位： | 1Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon Based Functional Materials and Devices, Soochow University, 199 Ren’ai Road, Suzhou, Jiangsu 215123, P.R. China 2Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, P.R. China 3Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai 200011, P.R. China. 4Department of Ophthalmology and Vision Science, Eye & ENT Hospital, Shanghai Medical School, Fudan University, 83 Fenyang Road, Shanghai 200031, China 5Department of orthopedics, Shanghai Yangpu Hospital Affiliated to Tongji University, Shanghai 200090, China |
摘要： | Choroidal melanoma, a common intraocular malignant tumor, relies on local radiotherapy and enucleation for treatment. However, cancer recurrence and visual impairment remain important challenges. Here, a therapeutic artificial vitreous body (AVB) hydrogel based on tetra-armed poly(ethylene glycol) was developed to control the recurrence of choroidal melanoma and preserve vision after vitrectomy. AVB loaded with melphalan (Mel) and anti-programmed cell death ligand-1 (aPDL1), was injectedafter surgical resection in the choroidal melanoma mouse model.Afterwards, the sequentially released Mel and aPDL1 from AVB could achieve a synergistic antitumor effect to inhibit tumor recurrence. Remarkably, AVB with similar physical properties to native vitreous body could maintain the normal structure and visual function of eye after vitrectomy, which has been evidenced by standard examinations of ophthalmology in the mouse model.Thus, the immunotherapeutic AVB may be a promising candidate as an infill biomaterial to assist surgical treatment of intraocular malignant tumors. |
