基于工程化细菌的创新疗法
方向介绍：
通过合成生物学或细菌表面工程等手段改造细菌，从而用于肿瘤或其他疾病治疗是目前新兴的研究方向。本实验室通过基因工程与编辑技术对细菌的趋化性、免疫调节功能、及导航定位功能进行调控，从而增强细菌的肿瘤靶向定植，进而释放免疫调节因子或癌细胞杀伤因子，实现高效精准治疗肿瘤的功能；另一方面，我们还在发展可在口服后高效定植于肠道的工程化益生菌，用于肠道疾病治疗或调控肠道微生物菌群。
代表性论文：
(1) Wu Y, Liu B, Yan Y, Chen M, Zhu Y, Liu N, Dong Z, Feng L*, Liu Z*, Thermal-responsive activation of tumor-homing engineered bacteria to trigger robust antitumor immunity post ablation therapy. Nature Communications,15(1): 10503 (2024)
(2) Bo Liu, Kaiwei Wang, Qiaofeng Li, Zhisheng Xiao, Zihao Chen, Yuting Zhang, Yuzhe Wu, Yuchun Xu, Yumin Wu*, Zhuang Liu* “Engineered VNP20009 expressing IL-15&15Rα augments anti-tumor immunity for bladder cancer treatment” Biomaterials, 315: 122951(2024)
(3) Chenya Wang, Liping Zhong, Jiachen Xu, Qi Zhuang, Fei Gong, Xiaojing Chen, Huiquan Tao, Cong Hu, Fuquan Huang, Nailin Yang, Junyan Li, Qi Zhao, Xinjun Sun, Yu Huo, Qian Chen, Yongxiang Zhao*, Rui Peng* , Zhuang Liu*.“Oncolytic mineralized bacteria as potent locally administered immunotherapeutics” Nature Biomedical Engineering, 8, 561-578 (2024)
(4) Jun Zhou, Maoyi Li, Qiufang Chen, Xinjie Li, Linfu Chen, Ziliang Dong, Wenjun Zhu, Yang Yang, Zhuang Liu* & Qian Chen*. “Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery” Nature Communications, 13, 3432 (2022)
(5) Zhijuan Yang, Yujie Zhu, Ziliang Dong, Yu Hao, Chunjie Wang, Quguang Li, Yumin Wu, Liangzhu Feng*, Zhuang Liu*. “Engineering bioluminescent bacteria to boost photodynamic therapy and systemic anti-tumor immunity for synergistic cancer treatment” Biomaterials, 281, 121332 (2021)
(6) Xuan Yi, Hailin Zhou, Yu Chao, Saisai Xiong, Jing Zhong, Zhifang Chai, Kai Yang*, and Zhuang Liu*. “Bacteria-triggered tumor-specific thrombosis to enable potent photothermal immunotherapy of cancer” Science Advances, 6(33): eaba3546 (2020)
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