基于生物材料的免疫工程与免疫治疗
方向介绍：
以免疫检查点疗法和免疫细胞疗法为代表的免疫治疗为肿瘤等疾病的治疗带来了新的机遇。本实验室设计构建了多种创新生物材料技术平台，用于辅助新型免疫疗法，相关研究多项已进入临床试验阶段。
主要研究方向：
- 肿瘤微环境调控辅助肿瘤免疫治疗
- 纳米疫苗与原位肿瘤疫苗技术
- 生物材料支架辅助免疫细胞治疗
- 免疫细胞在体工程化用于肿瘤和自身免疫疾病治疗
代表性论文：
(1) Chenya Wang, Liping Zhong, Jiachen Xu, Qi Zhuang, Fei Gong, Xiaojing Chen, Huiquan Tao, Cong Hu, Fuquan Huang, Nailin Yang, Junyan Li, Qi Zhao, Xinjun Sun, Yu Huo, Qian Chen, Yongxiang Zhao*, Rui Peng* , Zhuang Liu*.“Oncolytic mineralized bacteria as potent locally administered immunotherapeutics” Nature Biomedical Engineering, 8, 561-578 (2024)
(2) Jialu Xu, Yue Yu, Yue Zhang, Huaxing Dai, Qianyu Yang, Beilei Wang, Qingle Ma, Yitong Chen, Fang Xu, Xiaolin Shi, Zhuang Liu*, Chao Wang*. “Oral administration of garlic-derived nanoparticles improves cancer immunotherapy by inducing intestinal IFNγ-producing γδ T cells ”Nature Nanotechnology,19(10): 1569-78.(2024)
(3) Yu Chao , Zhuang Liu*. “Biomaterials tools to modulate the tumour microenvironment in immunotherapy” Nature Reviews Bioengineering, 1, 125-138 (2023)
(4) Yu Chao, Ting Wei, Qiaofeng Li, Bo Liu, Yu Hao, Muchao Chen, Yuzhe Wu, Fanxin Song , Qian Chen*, Zhuang Liu*. “Metformin-containing hydrogel scaffold to augment CAR-T therapy against post-surgical solid tumors” Biomaterials, 295,122052 (2023)
(5) Lele Sun, Fengyun Shen, Zijian Xiong, He Yang, Ziliang Dong, Jian Xiang, Qingyang Gu, Qunsheng Ji, Chunhai Fan, and Zhuang Liu*. “DNA Engineered Lymphocyte-Based Homologous Targeting Artificial Antigen-Presenting Cells for Personalized Cancer Immunotherapy” J. Am. Chem. Soc., 144,17,7634-7645 (2022
(6) Jun Xu, Jia Lv, Qi Zhuang, Zongjin Yang, Zhiqin Cao, Ligeng Xu, Pei Pei, Chenya Wang, Hanfei Wu, Ziliang Dong, Yu Chao, Chao Wang, Kai Yang, Rui Peng*, Yiyun Cheng* and Zhuang Liu*.A general strategy towards personalized nanovaccines based on fluoropolymers for post-surgical cancer immunotherapy” Nature Nanotechnology, 15, 1043-1052 (2020)
(7) Yu Chao, Chao Liang, Huiquan Tao, Yaran Du, Di Wu, Ziliang Dong, Qiutong Jin, Guobin Chen, Jun Xu, Zhisheng Xiao, Qian Chen, Chao Wang, Jian Chen and Zhuang Liu*.“Localized cock-tail chemo-immunotherapy after in situ gelation to trigger robust systemic antitumor immune responses.” Science Advances, 6(10),eaaz4204 (2020)
(8) Yu Chao, Ligeng Xu, Chao Liang, Liangzhu Feng, Jun Xu, Ziliang Dong, Longlong Tian, Xuan Yi, Kai Yang* and Zhuang Liu*. “Combined Local Immunostimulatory Radioisotope Therapy and Systemic Immune Checkpoint Blockade Imparts Potent Antitumour Responses” Nature Biomedical Engineering, 2, 611-621(2018)
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