Introduction:

Macromolecular drugs such as antibodies, peptides, nucleic acids, etc., play an increasingly important role in the treatment of various diseases. Different from the diversified delivery methods of small molecule drugs, large molecule drugs are difficult to effectively penetrate through various physiological barriers due to their large molecular weights,and thus most of them rely on injection administration in clinical use. An important research direction of our laboratory is the development of novel delivery carriers for needle-free delivery of macromolecular drugs. Our rationally designed carrier molecules can self-assemble with proteins to form nanoparticles, which could penetrate through various types of physiological barriers. Such technologies enable oral, eyedrop, transdermal and transmucosal delivery of macromolecular drugs. These innovative drug delivery technologies are expected to provide more convenient, safe, and effective treatment options for autoimmune diseases, metabolic diseases, eye diseases and other chronic diseases.

Selected Papers：

(1) Ming Shao; Yu Chai; Yutong Jiang; Xinyi Wu; Wenjie Xie; Jiayi Lu; Xuehui Fu; Yao He; Xiaofeng Zhang*; Han Zhang*; Zhuang Liu*. “Eye-Drop Nano-Formulation of Catalase Self-Assembled with Thiolated Chitosan for Effective Treatment of Dry Eye Disease”Advanced Materials, e2415353(2025)

(2) Wenjun Zhu, Ting Wei, Yuchun Xu, Qiutong Jin, Yu Chao, Jiaqi Lu, Jun Xu, Jiafei Zhu, Xiaoying Yan, Muchao Chen, Qian Chen *, Zhuang Liu*. “Non-invasive transdermal delivery of biomacromolecules with fluorocarbon-modified chitosan for melanoma immunotherapy and viral vaccines”Nature Communications, 15, 820 (2024)

(3) Jingjing Shen, Huiqin Gao, Linfu Chen, Yutong Jiang, Shu Li, Yu Chao, Nanhui Liu, Yufei Wang, Ting Wei, Yan Liu, Jipeng Li, Muchao Chen, Jiafei Zhu, Juan Liang, Xiaoyu Zhou, Xiaofeng Zhang*, Ping Gu*, Qian Chen*, Zhuang Liu*. “Eyedrop-based macromolecular ophthalmic drug delivery for ocular fundus disease treatment”Science Advances, 9, 4 (2023)

(4) Wenjun Zhu, Yu Chao, Qiutong Jin, Linfu Chen, Jingjing Shen, Jiafei Zhu, Yu Chai, Panhao Lu, Nailin Yang, Muchao Chen, Yang Yang*, Qian Chen*, and Zhuang Liu*. “Oral Delivery of Therapeutic Antibodies with a Transmucosal Polymeric Carrier” ACS Nano, 17, 5, 4373-4386 (2023)

(5) Guangzhi Li, Shupeng Wang, Dashi Deng, Zhisheng Xiao, Ziliang Dong, Zhiping Wang, Qifang Lei, Shan Gao, Guixiao Huang, Enpu Zhang, Guohua Zeng, Zhong Wen, Song Wu*, and Zhuang Liu*.“Fluorinated ChitosanTo Enhance Transmucosal Delivery of Sonosensitizer-Conjugated Catalase for Sonodynamic Bladder Cancer Treatment Post-intravesical Instillation” ACS Nano, 14, 2,1586-1599 (2020)